Prep the brisket: Trim excess fat from the brisket, leaving a thin fat cap to maintain moisture and flavor.
Season the brisket: Mix salt, pepper, paprika, garlic powder, and onion powder in a bowl. Rub the brisket generously with the seasoning, covering all sides. Let it rest for at least 1 hour, or refrigerate overnight for deeper flavor.
Prepare the smoker: Preheat your smoker to 225°F (107°C). Add your choice of wood chips (hickory or mesquite for a stronger flavor). Set up the water pan to help regulate moisture.
Smoke the brisket: Place the brisket in the smoker, fat side up. Close the smoker and cook at 225°F for approximately 6-8 hours, or until the internal temperature reaches 165°F (74°C).
Mist for moisture (optional): Every 2-3 hours, mist the brisket with apple juice or vinegar to maintain moisture and enhance flavor.
Wrap the brisket (optional): When the brisket reaches 165°F, wrap it tightly in aluminum foil (the "Texas crutch") to retain moisture and speed up the cooking process. Return it to the smoker.
Finish the brisket: Continue smoking until the internal temperature reaches 203°F (95°C), approximately 2-4 hours more.
Rest the brisket: Remove the brisket from the smoker and let it rest, wrapped in foil, for 30 minutes to 1 hour. This allows the juices to redistribute.
Slice and serve: Slice the brisket against the grain and serve immediately.